Healthspan Pharmacology
نویسندگان
چکیده
منابع مشابه
Translating longevity research into healthspan
At the beginning of the 20 century the names of deadly childhood diseases were whispered in fear. Everyone knew a family visited by the shadow of tuberculosis, rickets, polio or smallpox. Chickenpox and rubella brought their own forms of misery. Each disease presented in different ways, affected different organs and had distinct prognoses. Many of us will remember the endless cycles of bake sal...
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In this editorial of thefirst anniversary issue of EBioMedicine, we cannot help but reflect on aging. Tremendous biomedical successes over the last century have contributed to ever-increasing life expectancies. In its September 30, 2015 World report on ageing and health, the World Health Organization estimates that the global average life expectancy is now greater than 60 years. In developed na...
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A number of small molecules with the ability to extend the lifespan of multiple organisms have recently been discovered. Resveratrol, amongst the most prominent of these, has gained widespread attention due to its ability to extend the lifespan of yeast, worms, and flies, and its ability to protect against age-related diseases such as cancer, Alzheimer's, and diabetes in mammals. In this review...
متن کاملMetformin improves healthspan and lifespan in mice
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. Treatment with metformin mimics some of the benefits of calorie restriction, such as improved physical performance, increased insulin se...
متن کاملMitochondrial oxidative stress in aging and healthspan
The free radical theory of aging proposes that reactive oxygen species (ROS)-induced accumulation of damage to cellular macromolecules is a primary driving force of aging and a major determinant of lifespan. Although this theory is one of the most popular explanations for the cause of aging, several experimental rodent models of antioxidant manipulation have failed to affect lifespan. Moreover,...
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ژورنال
عنوان ژورنال: Rejuvenation Research
سال: 2015
ISSN: 1549-1684,1557-8577
DOI: 10.1089/rej.2015.1774